Relation Results

Summary

Name NRG1
Full Name Pro-neuregulin-1, membrane-bound isoform
Synonyms Pro-NRG1 | GGF, HGL, HRGA, NDF, SMDF
Primary ID Q02297
Links - -
Type protein
Relations 6
Function Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosi ...
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Type: Score: Layout: SPV 
0.7870.9020.9050.870.369NRG1ERBB2ERBB4ErbB receptor familyERBB3GDNF

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Relations
Regulator
Mechanism
target
score ℹ
+ NRG1up-regulates img/direct-activation.png binding ERBB2 0.787
Identifier Residue Sequence Organism Cell Line
SIGNOR-26875 Homo sapiens Breast Cancer Cell
pmid sentence
Direct interaction between heregulin and the two proteins was demonstrated by chemical cross-linking experiments using 125i-heregulin followed by immunoprecipitation with antibodies specific for erbb2 or erbb3.
Publications: 1 Organism: Homo Sapiens
+ NRG1up-regulates img/direct-activation.png binding ERBB4 0.902
Identifier Residue Sequence Organism Cell Line
SIGNOR-122053 Homo sapiens
pmid sentence
The neuregulins (also called heregulins and neu differentiation factors) nrg-1 and nrg-2 bind erbb-3 and erbb-4;and nrg-3 and nrg-4 bind erbb-4.
Publications: 1 Organism: Homo Sapiens
+ NRG1up-regulates img/direct-activation.png binding ErbB receptor family 0.905
Identifier Residue Sequence Organism Cell Line
SIGNOR-269870 Homo sapiens
pmid sentence
The neuregulins (also called heregulins and neu differentiation factors) nrg-1 and nrg-2 bind erbb-3 and erbb-4;and nrg-3 and nrg-4 bind erbb-4.
Publications: 1 Organism: Homo Sapiens
+ NRG1up-regulates img/direct-activation.png binding ERBB3 0.87
Identifier Residue Sequence Organism Cell Line
SIGNOR-26878 Homo sapiens Breast Cancer Cell
pmid sentence
The neuregulins (also called heregulins and neu differentiation factors) nrg-1 and nrg-2 bind erbb-3 and erbb-4;and nrg-3 and nrg-4 bind erbb-4 direct interaction between heregulin and the two proteins was demonstrated by chemical cross-linking experiments using 125i-heregulin followed by immunoprecipitation with antibodies specific for erbb2 or erbb3.
Identifier Residue Sequence Organism Cell Line
SIGNOR-26061 Homo sapiens
pmid sentence
The neuregulins (also called heregulins and neu differentiation factors) nrg-1 and nrg-2 bind erbb-3 and erbb-4;and nrg-3 and nrg-4 bind erbb-4 direct interaction between heregulin and the two proteins was demonstrated by chemical cross-linking experiments using 125i-heregulin followed by immunoprecipitation with antibodies specific for erbb2 or erbb3.
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ GDNFup-regulates quantity by expression img/indirect-activation.png transcriptional regulation NRG1 0.369
Identifier Residue Sequence Organism Cell Line
SIGNOR-252182 Rattus norvegicus Neural Stem Cell
pmid sentence
We characterize the network of 43 genes induced by GDNF overproduction of neuronal progenitor cells (ST14A), which mainly regulate migration and differentiation of neuronal progenitor cells.Laminin, Mpl3, Alcam, Bin1, Id1, Id2, Id3, neuregulin1, the ephrinB2-receptor, neuritin, focal adhesion kinase (FAK), Tc10, Pdpk1, clusterin, GTP-cyclooxygenase1, and follistatin are genes up-regulated by GDNF overexpression.
Publications: 1 Organism: Rattus Norvegicus
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