4.0
Summary
| Name |  CENPC
|
| Full Name | Centromere protein C |
| Synonyms | CENP-C, Centromere autoantigen C, Centromere protein C 1, CENP-C 1, Interphase centromere complex protein 7 | CENPC1, ICEN7 |
| Primary ID | Q03188 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CENPC | form complex 
binding
|
CCAN complex | 0.664 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CENPC | up-regulates activity 
binding
|
CENP-A nucleosome | 0.732 |
| Publications: | 1 | Organism: | Homo Sapiens | |