4.0
Summary
| Name |  AKR1C1
|
| Full Name | Aldo-keto reductase family 1 member C1 |
| Synonyms | 20-alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, 1.1.1.149, Chlordecone reductase homolog HAKRC, Dihydrodiol dehydrogenase 1/2, DD1/DD2, High-affinity hepatic bile acid-binding protein, HBAB, Indanol dehydrogenase, 1.1.1.112, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, 1.3.1.20 | DDH, DDH1 |
| Primary ID | Q04828 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Inhibitors | hexestrol |
| Function | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). |
chemical inhibition