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Summary
Name
ICA1
Full Name
Islet cell autoantigen 1
Synonyms
69 kDa islet cell autoantigen, ICA69, Islet cell autoantigen p69, ICAp69, p69 |
Primary ID
Q05084
Links
-
-
Type
protein
Relations
1
Function
May play a role in neurotransmitter secretion.
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by mechanism
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transcriptional regulation
by effect
none
down-regulates quantity by repression
by organism:
none
by tissue:
none
by cell-line
none
Relations
Regulator
Mechanism
target
score
ℹ
+
AIRE
down-regulates quantity by repression
transcriptional regulation
ICA1
0.371
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-268973
pmid
sentence
22447927
Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression.
Publications:
1