| + |
DEAF1 | up-regulates quantity by expression 
transcriptional regulation
|
EN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269062 |
|
|
Homo sapiens |
Keratinocyte Cell Line |
| pmid |
sentence |
| 31145909 |
Deaf1 is the first transcription factor implicated in the regulation of En1, a critical determinant of eccrine fate, within keratinocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EN1 | down-regulates quantity by repression 
transcriptional regulation
|
FGF8 |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265776 |
|
|
Mus musculus |
CCE Cell |
| pmid |
sentence |
| 10026229 |
Our results in ES cells suggest that Engrailed inhibits Fgf8 expression in the absence of Pbx1. We identified single Engrailed- and Pbx-binding sites in the Fgf8 intron that inhibit expression of Fgf8 in mouse ES cells, but that together can allow full Fgf8 expression. Our data support the model that Engrailed heterodimerized with Pbx might activate transcription, while Engrailed or Pbx proteins alone might repress transcription |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265802 |
|
|
Mus musculus |
CCE Cell |
| pmid |
sentence |
| 10026229 |
Our results in ES cells suggest that Engrailed inhibits Fgf8 expression in the absence of Pbx1. We identified single Engrailed- and Pbx-binding sites in the Fgf8 intron that inhibit expression of Fgf8 in mouse ES cells, but that together can allow full Fgf8 expression. Our data support the model that Engrailed heterodimerized with Pbx might activate transcription, while Engrailed or Pbx proteins alone might repress transcription |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
HNuRF | up-regulates quantity by expression
transcriptional regulation
|
EN1 |
0.322 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268839 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14609955 |
Human NURF (hNURF) is enriched in brain, and we demonstrate that it regulates human Engrailed, a homeodomain protein that regulates neuronal development in the mid-hindbrain. Furthermore, we show that hNURF potentiates neurite outgrowth in cell culture. Taken together, our data suggess a role for an ISWI complex in neuronal growth. ) ChIP assays localize hNURF specifically to engrailed-1 (en-1) and engrailed-2 (en-2) promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
3.0
EN1
- 
- 