3.0
Summary
| Name |  RUNX1T1
|
| Full Name | Protein CBFA2T1 |
| Synonyms | Cyclin-D-related protein, Eight twenty one protein, Protein ETO, Protein MTG8, Zinc finger MYND domain-containing protein 2 | AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 |
| Primary ID | Q06455 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). |
transcriptional regulation