Summary

Name POLE
Full Name DNA polymerase epsilon catalytic subunit A
Synonyms DNA polymerase II subunit A | POLE1
Primary ID Q07864
Links - -
Type protein
Relations 1
Function Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374).

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Relations

Regulator Mechanism target score ℹ
+ POLEform complex img/form-complex.png binding DNA polymerase epsilon 0.92
Publications: 1 Organism: Homo Sapiens