| + |
DNA polymerase epsilon | up-regulates 
|
DNA_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265722 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10801849 |
HeLa pol epsilon was initially purified as a soluble factor that restored repair synthesis to cytosol-depleted, UV-irradiated permeabilized human fibroblasts (11). By reconstituting the nucleotide excision repair (NER) process from purified proteins, Shivji et al. (12) further showed that mammalian pol epsilon was the most efficient enzyme in performing gap-filling DNA synthesis during NER. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLE | form complex 
binding
|
DNA polymerase epsilon |
0.921 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265520 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10801849 |
Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCNA | up-regulates activity 
binding
|
DNA polymerase epsilon |
0.557 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265512 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 12930972 |
Processive DNA synthesis by DNA polymerases delta and epsilon requires the cellular replication factor C (RF‐C) and proliferating cell nuclear antigen (PCNA). |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
POLE2 | form complex
binding
|
DNA polymerase epsilon |
0.919 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265519 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10801849 |
Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLE3 | form complex
binding
|
DNA polymerase epsilon |
0.902 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265522 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10801849 |
Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNA polymerase epsilon | up-regulates
|
DNA_replication |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265514 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 12930972 |
Processive DNA synthesis by DNA polymerases delta and epsilon requires the cellular replication factor C (RF‐C) and proliferating cell nuclear antigen (PCNA). |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
POLE4 | form complex
binding
|
DNA polymerase epsilon |
0.913 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265521 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10801849 |
Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DNA polymerase epsilon
CPX-2108