Relation Results

Summary

Name ELP6
Full Name Elongator complex protein 6
Synonyms Angiotonin-transactivated protein 1, Protein TMEM103 | ATP1, C3orf75, TMEM103
Primary ID Q0PNE2
Links - -
Type protein
Relations 1
Function Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-me ...
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Type: Score: Layout: SPV 
0.77ELP6Elongator complex

Relations

Regulator
Mechanism
target
score
+ form complex img/form-complex.png binding Elongator complex 0.77
Identifier Residue Sequence Organism Cell Line
SIGNOR-269713 Homo sapiens
pmid sentence
Elongator is a highly conserved eukaryotic protein complex consisting of two sets of six Elp proteins, while homologues of its catalytic subunit Elp3 are found in all the kingdoms of life. Although it was originally described as a transcription elongation factor, cumulating evidence suggests that its primary function is catalyzing tRNA modifications. In humans, defects in Elongator subunits are associated with neurological disorders and cancer.
Publications: 1 Organism: Homo Sapiens
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