4.0
Summary
| Name |  INCA1View Modifications |
| Full Name | Protein INCA1 |
| Synonyms | Inhibitor of CDK interacting with cyclin A1 | |
| Primary ID | Q0VD86 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity). {ECO:0000250|UniProtKB:Q6PKN7, ECO:0000269|PubMed:21540187}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CyclinA2/CDK2 |
phosphorylation
|
INCA1 | 0.329 |
| Publications: | 2 | Organism: | In Vitro | |