Summary

Name WASHC5
Full Name WASH complex subunit 5
Synonyms Strumpellin, WASH complex subunit strumpellin | KIAA0196
Primary ID Q12768
Links - -
Type protein
Relations 1
Function Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666).

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Relations

Regulator Mechanism target score ℹ
+ WASHC5form complex img/form-complex.png binding WASH complex 0.2
Publications: 1