| + |
CLOCK | up-regulates quantity by expression 
transcriptional regulation
|
DPYD |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253986 |
|
|
|
|
| pmid |
sentence |
| 17699798 |
Regulation of Genes of the Circadian Clock in Human Colon Cancer: Reduced Period-1 and Dihydropyrimidine Dehydrogenase Transcription Correlates in High-Grade Tumors| The highly significant correlation of DPD mRNA with Per1 mRNA expression suggests control of DPD transcription by the endogenous cellular clock, which is more pronounced in women. |
|
| Publications: |
1 |
| + |
DPYD | down-regulates quantity 
chemical modification
|
5-fluorouracil |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253987 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10499634 |
Dihydropyrimidine dehydrogenase (DPD) is responsible for degradation of the pyrimidines uracil and thymine and the inactivation of the chemotherapeutic agent 5-fluorouracil. DPD activity is highly variable in cancer populations, and this variation may influence the antitumor efficacy of 5-fluorouracil. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DPYD | down-regulates quantity
chemical modification
|
uracil |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253988 |
|
|
|
|
| pmid |
sentence |
| 10499634 |
Dihydropyrimidine dehydrogenase (DPD) is responsible for degradation of the pyrimidines uracil and thymine and the inactivation of the chemotherapeutic agent 5-fluorouracil. DPD activity is highly variable in cancer populations, and this variation may influence the antitumor efficacy of 5-fluorouracil. |
|
| Publications: |
1 |
| + |
DPYD | down-regulates quantity
chemical modification
|
thymine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253989 |
|
|
|
|
| pmid |
sentence |
| 10499634 |
Dihydropyrimidine dehydrogenase (DPD) is responsible for degradation of the pyrimidines uracil and thymine and the inactivation of the chemotherapeutic agent 5-fluorouracil. DPD activity is highly variable in cancer populations, and this variation may influence the antitumor efficacy of 5-fluorouracil. |
|
| Publications: |
1 |
3.0
DPYD
- 
- 