| + |
MLLT11 | up-regulates 
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259201 |
|
|
Mus musculus |
OP-9 Cell |
| pmid |
sentence |
| 21715312 |
Our results indicate that AF1q cooperates with the Notch signaling pathway to foster the emergence of BM prothymocytes and drive subsequent intrathymic specification toward the T-cell lineage. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MLLT11 | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259107 |
|
|
Homo sapiens |
MCF-10A Cell, Mammary Epithelial Cell Line, MDA-MB-231 Cell |
| pmid |
sentence |
| 26079538 |
In addition, enhanced AF1q expression promotes breast cancer cell proliferation, migration, mammosphere formation, and chemo-resistance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLLT11 | up-regulates activity 
binding
|
TCF7 |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259108 |
|
|
in vitro |
|
| pmid |
sentence |
| 26079538 |
Here, we show that AF1q specifically binds to T-cell-factor-7 (TCF7) in the Wnt signaling pathway and results in transcriptional activation of CD44 as well as multiple downstream targets of the TCF7/LEF1. Super-shift and electrophoretic mobility shift assay (EMSA) further confirmed that AF1q directly interacted with TCF7 and enhanced the binding affinity of the complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
MLLT11
- 
- 