Summary

Name GRM1
Full Name Metabotropic glutamate receptor 1
Synonyms mGluR1 | GPRC1A, MGLUR1
Primary ID Q13255
Links - -
Type protein
Relations 5
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890). May function in the light response in the retina (By similarity).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PRKCAdown-regulates activity img/direct_inhibition.png phosphorylation GRM1 0.393
Publications: 1 Organism: Homo Sapiens
+ GRM1up-regulates activity img/direct-activation.png binding GNAS 0.385
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ GRM1up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Publications: 1 Organism: Homo Sapiens
+ GRM1up-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Publications: 1 Organism: Homo Sapiens
+ glutamic acidup-regulates activity img/direct-activation.png chemical activation GRM1 0.8
Publications: 1 Organism: Homo Sapiens