Summary

Name PRKCA
Full Name Protein kinase C alpha type
Synonyms PKC-A, PKC-alpha | PKCA, PRKACA
Primary ID P17252
Links - -
Type protein
Relations 331
Pathways T cell activation
Inhibitors bisindolylmaleimide i; 3-(1-methyl-3-indolyl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-3-indolyl]pyrrole-2,5-dione
Function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation VIM 0.14
Publications: 11 Organism: In Vitro,
+ img/unknown.png phosphorylation MARCKS 0.31
Publications: 9 Organism: In Vitro, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KCNE1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PEA15 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ img/unknown.png phosphorylation INSR 0.2
Publications: 3 Organism: In Vitro
+ img/unknown.png phosphorylation CD163 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HAND1 0.14
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation VCL 0.14
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PLCB3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLEK 0.2
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TRPM4 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SRC 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation KCNMA1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates img/direct_inhibition.png phosphorylation PLCG1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ down-regulates activity img/direct_inhibition.png phosphorylation GFAP 0.14
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.14
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation EGLN2 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ITGB4 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DLX3 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation DLX3 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation SHC1 0.36
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation HSPB8 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HSPB8 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ img/unknown.png phosphorylation MBP 0.14
Publications: 7 Organism: In Vitro
+ img/unknown.png phosphorylation GRIN2A 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation IQGAP1 0.23
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NR1H4 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1A 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MARCKS 0.22
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation GNAZ 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ img/unknown.png phosphorylation SNAP23 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SRF 0.2
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation TNNI3 0.2
Publications: 4 Organism: In Vitro
+ img/unknown.png phosphorylation, RPL10 0.14
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation NOXA1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SDC4 0.22
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation SNAP25 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SNAP25 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SDC2 0.14
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation RALB 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates img/direct-activation.png phosphorylation PLD1 0.14
Publications: 3 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation MYL9 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CORO1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KCNJ13 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GFPT1 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation EIF4E 0.22
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation GSK3A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HMGN1 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RRAD 0.14
Publications: 5 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GJB1 0.14
Publications: 2 Organism: In Vitro,
+ down-regulates img/direct_inhibition.png phosphorylation CFL1 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAF1 0.28
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EIF6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLD2 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HMGN2 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HDAC5 0.14
Publications: 2 Organism: Rattus Norvegicus
+ img/unknown.png phosphorylation ANXA2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GJA1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EWSR1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation IL2RA 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ANXA1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation F11R 0.2
Publications: 2 Organism: Homo Sapiens, In Vitro
+ up-regulates img/direct-activation.png phosphorylation F3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRK2 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NFATC1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation TRPV5 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1 0.22
Publications: 8 Organism: Homo Sapiens
+ img/unknown.png phosphorylation STXBP1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation ARHGDIB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PDE3A 0.14
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CLIP1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SPAG1 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation PTGIR 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RHO 0.28
Publications: 6 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation OCLN 0.14
Publications: 1 Organism: Canis Lupus Familiaris
+ img/unknown.png phosphorylation OPRD1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PSEN1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RORA 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HLA-A 0.14
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation NRGN 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation PA2G4 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GJA1 0.2
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation HES1 0.14
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.22
Publications: 1 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation VTN 0.22
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PTPN12 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CYTH2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ADRA1B 0.14
Publications: 5 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation HRH1 0.2
Publications: 3 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation NFE2L2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LMNA 0.28
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PIP5K1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TNNI3 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ img/unknown.png phosphorylation LCK 0.22
Publications: 1 Organism: In Vitro
Pathways:T cell activation
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP1 0.14
Publications: 4 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DGKZ 0.14
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation CTPS1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHAT 0.14
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RPS6KB2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NKX3-1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.34
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation THOC5 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation LMNA 0.28
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation KRT18 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation GMFB 0.14
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation NOX5 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KCNQ2 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png phosphorylation DDX5 0.14
Publications: 1 Organism: In Vitro
+ up-regulates quantity img/direct-activation.png phosphorylation KCNQ2 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png phosphorylation PTPN6 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN11 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CBL 0.14
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.14
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates quantity img/direct_inhibition.png dephosphorylation PRKCA 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png dephosphorylation PRKCA 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCA 0.22
Publications: 2 Organism: Homo Sapiens
Pathways:T cell activation
+ down-regulates activity img/direct_inhibition.png phosphorylation DGKD 0.14
Publications: 2 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation GRIA2 0.2
Publications: 3 Organism: In Vitro, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CFTR 0.14
Publications: 2 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ADD3 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TRPC3 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png phosphorylation ACO1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png phosphorylation ADD2 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation ADD1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation PRKD1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KIT 0.36
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KIT 0.36
Publications: 4 Organism: Sus Scrofa
+ up-regulates img/direct-activation.png phosphorylation CDKN2D 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TNNI3 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation DNM1 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation GRIA1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.14
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation GRIA4 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ADAP1 0.28
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation PLCB1 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPA1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MET 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NPHS1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MYOD1 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation DLX3 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation AQP1 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation NOXO1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HABP4 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PPP1R14A 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Brain
+ img/unknown.png phosphorylation PPP1R14A 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation CD5 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CD5 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTPS1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PFKFB2 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation NOS3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EZR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKG1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EGFR 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GRM1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation APLP2 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation ITGB2 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRIA4 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CASR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EDF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKCA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PRKCA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation, binding PRKCA 0.33
Publications: 4 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation PRKCA 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png NOS1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/direct-activation.png transcriptional activation PRKCA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding, chemical activation PRKCA 0.51
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/direct-activation.png transcriptional activation PRKCA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation PRKCA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Apoptosis 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCA 0.3
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ down-regulates activity img/direct_inhibition.png ITPKA 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CREBBP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PRKCA 0.33
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png binding PRKCA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ITPKB 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PRKCA 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation PRKCA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Cell_death 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PRKCA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation PRKCA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.39
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PRKCA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLA2G4A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png PRKCA 0.14
Publications: 1 Organism: Homo Sapiens