Summary

Name PRKCA
Full Name Protein kinase C alpha type
Synonyms PKC-A, PKC-alpha | PKCA, PRKACA
Primary ID P17252
Links - -
Type protein
Relations 420
Pathways Axon guidance, B-cell activation, GPCR_CRC, GPCR_HCC, Mitochondrial dynamics in T cell exhaustion, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling
Inhibitors 3-(1-methyl-3-indolyl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-3-indolyl]pyrrole-2,5-dione; midostaurin; bisindolylmaleimide i
Function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteosomal degradation (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation VIM 0.285
Publications: 10 Organism: In Vitro
+ img/unknown.png phosphorylation MARCKS 0.729
Publications: 9 Organism: In Vitro, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KCNE1 0.308
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PEA15 0.385
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ img/unknown.png phosphorylation INSR 0.349
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation LRRK1 0.2
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation FMNL2 0.2
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation CD163 0.324
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HAND1 0.289
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation VCL 0.391
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PLCB3 0.478
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLEK 0.28
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TRPM4 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EIF4G1 0.258
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SRC 0.598
Publications: 1 Organism: In Vitro
Pathways:Axon guidance
+ up-regulates img/direct-activation.png phosphorylation KCNMA1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PLCG1 0.554
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation, VEGF Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation GFAP 0.367
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.47
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation EGLN2 0.361
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ITGB4 0.529
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DLX3 0.308
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation DLX3 0.308
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.403
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation HSPB8 0.308
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HSPB8 0.308
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ img/unknown.png phosphorylation MBP 0.491
Publications: 7 Organism: In Vitro
+ img/unknown.png phosphorylation GRIN2A 0.507
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TWIST1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IQGAP1 0.258
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NR1H4 0.326
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TBXA2R (isoform 2) 0.519
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDKN1A 0.377
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MARCKS 0.729
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation GNAZ 0.439
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates activity img/direct_inhibition.png phosphorylation ATP1A1 0.33
Publications: 1 Organism: Mycolicibacterium Chitae
+ img/unknown.png phosphorylation SNAP23 0.33
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SRF 0.246
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation TRPV4 0.378
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ARRB1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MBD4 0.2
Publications: 2
+ down-regulates activity img/direct_inhibition.png phosphorylation TNNI3 0.344
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation, RPL10 0.308
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation NOXA1 0.291
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ARX 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAB11A 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SDC4 0.731
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation FBXW7 0.346
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDC42EP4 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CSNK1D 0.2
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GSTP1 0.2
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation SDC2 0.372
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation SNAP25 0.354
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SNAP25 0.354
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CFLAR 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RALB 0.291
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MYL9 0.278
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CORO1B 0.325
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLD1 0.713
Publications: 3 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation KCNJ13 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GFPT1 0.308
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation EIF4E 0.384
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation TOP1 0.2
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation GSK3A 0.346
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HMGN1 0.308
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RRAD 0.289
Publications: 5 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation FLNC 0.339
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PRKCA 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKCA 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GJB1 0.363
Publications: 2 Organism: In Vitro,
+ up-regulates activity img/direct-activation.png phosphorylation TNNI3 0.344
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CFL1 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Axon guidance
+ img/unknown.png phosphorylation RAF1 0.556
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EIF6 0.317
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SLC6A9 (isoform 2) 0.332
Publications: 5 Organism: Sus Scrofa
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.387
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ARHGEF1 0.441
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLD2 0.691
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HMGN2 0.29
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HDAC5 0.2
Publications: 2 Organism: Rattus Norvegicus
+ img/unknown.png phosphorylation ANXA2 0.357
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GJA1 0.537
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DGKZ 0.505
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation EWSR1 0.332
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation IL2RA 0.264
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ANXA1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PITPNC1 0.32
Publications: 2 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation F11R 0.323
Publications: 2 Organism: Homo Sapiens, In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ICOSLG 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation F3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRK2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NFATC1 0.385
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SHOC2 0.2
Publications: 2
+ up-regulates activity img/direct-activation.png phosphorylation TRPV5 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1 0.552
Publications: 8 Organism: Homo Sapiens
+ img/unknown.png phosphorylation STXBP1 0.379
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation ARHGDIB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PDE3A 0.2
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CLIP1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TACSTD2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPT (isoform 2) 0.266
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation SPAG1 0.308
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation PTGIR 0.324
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTNNB1 0.414
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1R16B 0.2
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation RHO 0.441
Publications: 6 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation OCLN 0.365
Publications: 1 Organism: Canis Lupus Familiaris
+ img/unknown.png phosphorylation OPRD1 0.349
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PSEN1 0.264
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RORA 0.252
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation UNC5A 0.2
Publications: 2 Organism: Rattus Norvegicus
Pathways:Axon guidance
+ img/unknown.png phosphorylation HLA-A 0.323
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation NRGN 0.395
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation PA2G4 0.431
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GJA1 0.537
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation HES1 0.33
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.439
Publications: 1 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation VTN 0.318
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TP73 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PTPN12 0.323
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation VIM 0.285
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation CYTH2 0.308
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ADRA1B 0.391
Publications: 5 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation HRH1 0.2
Publications: 3 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation NFE2L2 0.534
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LMNA 0.363
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP2R5A 0.342
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PIP5K1B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KIR3DL1 0.2
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation LCK 0.323
Publications: 1 Organism: In Vitro
Pathways:T cell activation
+ down-regulates img/direct_inhibition.png phosphorylation TNNI3 0.344
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ULK1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation UGT1A3 0.2
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.556
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GABRR1 0.337
Publications: 4 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation LRP1 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTPS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHAT 0.384
Publications: 5 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPS6KB2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NKX3-1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FERMT3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.556
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation THOC5 0.328
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JAK2 0.26
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation LMNA 0.363
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation GMFB 0.323
Publications: 3 Organism: In Vitro
+ img/unknown.png phosphorylation KRT18 0.308
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation NOX5 0.2
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KCNQ2 0.325
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png phosphorylation DDX5 0.336
Publications: 1 Organism: In Vitro
+ up-regulates quantity img/direct-activation.png phosphorylation KCNQ2 0.325
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png phosphorylation PTPN6 0.365
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN11 0.324
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CBL 0.323
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.358
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates quantity img/direct_inhibition.png dephosphorylation PRKCA 0.253
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png dephosphorylation PRKCA 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCA 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Axon guidance, B-cell activation, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation DGKD 0.367
Publications: 2 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation GRIA2 0.708
Publications: 3 Organism: In Vitro, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CFTR 0.4
Publications: 2 Organism: In Vitro
+ down-regulates quantity img/direct_inhibition.png phosphorylation MEP1B 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ADD3 0.335
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TRPC3 0.349
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png phosphorylation PRKD2 0.391
Publications: 3
+ down-regulates img/direct_inhibition.png phosphorylation ACO1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png phosphorylation ADD2 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ADD1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation PRKD1 0.439
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KIT 0.529
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KIT 0.529
Publications: 4 Organism: Sus Scrofa
+ up-regulates img/direct-activation.png phosphorylation CDKN2D 0.2
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TNNI3 0.344
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation DNM1 0.335
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation GRIA1 0.714
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.417
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation GRIA4 0.568
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ADAP1 0.318
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNND1 0.252
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PLCB1 0.713
Publications: 1 Organism: Mus Musculus
Pathways:Thyroid Hormone Metabolism
+ up-regulates activity img/direct-activation.png phosphorylation GRIN1 0.419
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.358
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPA1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MET 0.256
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GPM6A 0.324
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation NPHS1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MYOD1 0.364
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation L1CAM 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DLX3 0.308
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CYBA 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation NCF4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AQP1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation SRF 0.246
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation RAB37 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KCNJ1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CSPG4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RALBP1 0.39
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation NOXO1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HABP4 0.29
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPP1R14A 0.521
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CD5 0.34
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CD5 0.34
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTPS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PFKFB2 0.441
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation NOS3 0.301
Publications: 1 Organism: Homo Sapiens
Pathways:VEGF Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation KCNJ4 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation EZR 0.545
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKG1 0.345
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.607
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GRM1 0.386
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation APLP2 0.341
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation ITGB2 0.342
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRIA4 0.568
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CASR 0.352
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EDF1 0.302
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKCA 0.393
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png binding PRKCA 0.802
Publications: 1 Organism: Rattus Norvegicus
Pathways:Axon guidance
+ down-regulates img/direct_inhibition.png phosphorylation CREBBP 0.261
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ up-regulates activity img/direct-activation.png phosphorylation MGluR 0.554
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition PRKCA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PRKCA 0.439
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PRKCA 0.385
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png NOS1 0.51
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PRKCA 0.414
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation, VEGF Signaling
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, VEGF Signaling
+ down-regulates activity img/direct_inhibition.png ITPKA 0.371
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation AMPA 0.714
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding, chemical activation PRKCA 0.8
Publications: 4 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PRKCA 0.385
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation PRKCA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCA 0.554
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation, VEGF Signaling
+ down-regulates img/indirect_inhibition.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RGS7 0.365
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding PRKCA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PRKCA 0.439
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TTN 0.272
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization PRKCA 0.46
Publications: 1
+ up-regulates img/indirect-activation.png PRKCA 0.445
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PRKCA 0.393
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation PRKCA 0.8
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:Axon guidance, B-cell activation, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling
+ down-regulates activity img/direct_inhibition.png chemical inhibition PRKCA 0.8
Publications: 1
+ down-regulates activity img/direct_inhibition.png ITPKB 0.361
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding PRKCA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation PRKCA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PRKCA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling
+ up-regulates img/direct-activation.png phosphorylation PLA2G4A 0.563
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Cell_death 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PRKCA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation PRKCA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, Thyroid Hormone Metabolism, VEGF Signaling