Summary

Name DYNC1I2
Full Name Cytoplasmic dynein 1 intermediate chain 2
Synonyms Cytoplasmic dynein intermediate chain 2, Dynein intermediate chain 2, cytosolic, DH IC-2 | DNCI2, DNCIC2
Primary ID Q13409
Links - -
Type protein
Relations 2
Function Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation DYNC1I2 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination DYNC1I2 0.304
Publications: 1 Organism: In Vitro