+ |
CSNK2A1 | up-regulates activity
phosphorylation
|
TCOF1 |
0.309 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265086 |
Thr210 |
TSSSSDEtDVEGKPS |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
25064736 |
Phosphorylated Thr 210 in Treacle is the major interaction site for NBS1|A purified GST fragment of this region was efficiently phosphorylated by CK2 in vitro (Supplementary Fig. 4; T-2) and this fragment pulled down the MRN complex from Hela nuclear extracts only when previously phosphorylated by CK2 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TCOF1 | up-regulates activity
relocalization
|
NBN |
0.324 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265085 |
|
|
Homo sapiens |
|
pmid |
sentence |
25064736 |
We further identify TCOF1 (also known as Treacle), a nucleolar factor implicated in ribosome biogenesis and mutated in Treacher Collins syndrome, as an interaction partner of NBS1, and demonstrate that NBS1 translocation and accumulation in the nucleoli is Treacle dependent. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |