Summary

Name SF3B2
Full Name Splicing factor 3B subunit 2
Synonyms Pre-mRNA-splicing factor SF3b 145 kDa subunit, SF3b145, Spliceosome-associated protein 145, SAP 145 | SAP145
Primary ID Q13435
Links - -
Type protein
Relations 2
Function Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).

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Relations

Regulator Mechanism target score ℹ
+ SF3B2form complex img/form-complex.png binding SF3b 0.92
Publications: 1 Organism: Homo Sapiens
+ SF3B2form complex img/form-complex.png binding U2 snRNP complex 0.777
Publications: 1 Organism: Homo Sapiens