Summary

Name MADCAM1
Full Name Mucosal addressin cell adhesion molecule 1
Synonyms MAdCAM-1, hMAdCAM-1 |
Primary ID Q13477
Links - -
Type protein
Relations 2
Function Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MADCAM1 0.446
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MADCAM1 0.2
Publications: 1 Organism: Homo Sapiens