Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272721 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
22009753 |
Here, we found that the level of LAPTM5 protein is regulated negatively by the degradation through ubiquitination by ITCH, an E3 ubiquitin ligase. ITCH directly binds to the PPxY motif of LAPTM5 via its WW domains and promotes ubiquitination through a HECT-type ligase domain. |
|