| + |
PKA | up-regulates activity 
phosphorylation
|
IQGAP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273742 |
Thr716 |
EYMHRRQtFIDNTDS |
Homo sapiens |
|
| pmid |
sentence |
| 21776420 |
We show that IQGAP2 is regulated by an interaction with the A-kinase anchoring protein AKAP220. Phosphorylation of IQGAP2 via AKAP220-anchored PKA leads to enhanced Rac binding. Since AKAPs function to direct PKA toward specific substrates, we proposed that the formation of an IQGAP2/AKAP220/PKA ternary complex sharpens the response to cAMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKAP11 | up-regulates activity
binding
|
IQGAP2 |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273740 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21776420 |
We show that IQGAP2 is regulated by an interaction with the A-kinase anchoring protein AKAP220. Phosphorylation of IQGAP2 via AKAP220-anchored PKA leads to enhanced Rac binding. Since AKAPs function to direct PKA toward specific substrates, we proposed that the formation of an IQGAP2/AKAP220/PKA ternary complex sharpens the response to cAMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IQGAP2
- 
- 