Summary

Name TNFAIP1
Full Name BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
Synonyms hBACURD2, BTB/POZ domain-containing protein TNFAIP1, Protein B12, Tumor necrosis factor, alpha-induced protein 1, endothelial | BACURD2, EDP1
Primary ID Q13829
Links - -
Type protein
Relations 3
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation TNFAIP1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TNFAIP1 0.476
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding RHOA 0.357
Publications: 1 Organism: Homo Sapiens