3.0
Summary
| Name |  TNFAIP1View Modifications |
| Full Name | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 |
| Synonyms | hBACURD2, BTB/POZ domain-containing protein TNFAIP1, Protein B12, Tumor necrosis factor, alpha-induced protein 1, endothelial | BACURD2, EDP1 |
| Primary ID | Q13829 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | up-regulates 
phosphorylation
|
TNFAIP1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CUL3 | up-regulates activity
binding
|
TNFAIP1 | 0.473 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TNFAIP1 | down-regulates quantity 
binding
|
RHOA | 0.356 |
| Publications: | 1 | Organism: | Homo Sapiens | |