Summary

Name PDE1C
Full Name Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Synonyms Cam-PDE 1C, hCam-3 |
Primary ID Q14123
Links - -
Type protein
Relations 2
Pathways FAP: In vitro induction of adipogenesis, FAP: IBMX/rosiglitazone, Pericyte: In vitro induction of adipogenesis
Inhibitors 3-isobutyl-1-methyl-7H-xanthine
Function Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8557689, PubMed:29860631). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).

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Relations

Regulator Mechanism target score ℹ
+ PDE1Cdown-regulates quantity img/direct_inhibition.png chemical modification 3',5'-cyclic AMP 0.8
Publications: 1 Organism: Homo Sapiens
+ 3-isobutyl-1-methyl-7H-xanthinedown-regulates activity img/direct_inhibition.png chemical inhibition PDE1C 0.8
Publications: 1 Organism: Homo Sapiens