Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-170972 |
|
|
Homo sapiens |
|
pmid |
sentence |
21210296 |
Permeabilization of the outer mitochondrial membrane allows the leakage of at least five apoptotic mediators from the mitochondrial intermembrane space, such as cyt c, (diablo/diablo), htra2/omi, apoptosis-inducing factors (aif), and endonuclease g. Such modifications result in their activation and translocation to outer mitochondrial membrane (omm) which helps it to interact with multidomain pro-apototic members, bax/baklike proteins, leading to their oligomerization and formation of pore. |
|