3.0
Summary
| Name |  PTK2BView Modifications |
| Full Name | Protein-tyrosine kinase 2-beta |
| Synonyms | Calcium-dependent tyrosine kinase, CADTK, Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta, CAK-beta, CAKB, Focal adhesion kinase 2, FADK 2, Proline-rich tyrosine kinase 2, Related adhesion focal tyrosine kinase, RAFTK | FAK2, PYK2, RAFTK |
| Primary ID | Q14289 |
| Links |  -  -  |
| Type | protein |
| Relations | 17 |
| Inhibitors | N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]methanesulfonamide |
| Function | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PTK2B |
phosphorylation
|
SNCA | 0.32 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | PTK2B | down-regulates activity 
phosphorylation
|
ASAP1 | 0.469 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PTK2B | up-regulates 
phosphorylation
|
PTK2B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN6 | down-regulates
dephosphorylation
|
PTK2B | 0.365 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN12 | down-regulates activity
dephosphorylation
|
PTK2B | 0.562 |
| Publications: | 3 | Organism: | Rattus Norvegicus, Homo Sapiens | |
| + | SRC | up-regulates
phosphorylation
|
PTK2B | 0.607 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTK2B | up-regulates
phosphorylation
|
PTK2 | 0.503 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTK2B | up-regulates activity
phosphorylation
|
TGFB1I1 | 0.734 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | PTK2B | down-regulates
phosphorylation
|
NOS3 | 0.315 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PTPN11 | down-regulates activity
dephosphorylation
|
PTK2B | 0.714 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]methanesulfonamide | down-regulates
chemical inhibition
|
PTK2B | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTK2B | up-regulates activity
phosphorylation
|
STAP1 | 0.358 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTK2B | up-regulates activity
phosphorylation
|
ASAP2 | 0.541 |
| Publications: | 1 | Organism: | Homo Sapiens | |