| + |
FAT1 | up-regulates activity 
binding
|
ENAH |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282692 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15343270 |
FAT1 is localized to the leading edge of lamellipodia, filopodia, and microspike tips where FAT1 directly interacts with Ena/VASP proteins that regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, FAT1 cytoplasmic domain recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. In an epithelial cell wound model, FAT1 knockdown decreased recruitment of endogenous VASP to the leading edge and resulted in impairment of lamellipodial dynamics, failure of polarization, and an attenuation of cell migration. FAT1 binds to and colocalizes with VASP and Mena via two EVH1-binding domains |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FAT1 | up-regulates activity
binding
|
VASP |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282693 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15343270 |
FAT1 is localized to the leading edge of lamellipodia, filopodia, and microspike tips where FAT1 directly interacts with Ena/VASP proteins that regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, FAT1 cytoplasmic domain recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. In an epithelial cell wound model, FAT1 knockdown decreased recruitment of endogenous VASP to the leading edge and resulted in impairment of lamellipodial dynamics, failure of polarization, and an attenuation of cell migration. FAT1 binds to and colocalizes with VASP and Mena via two EVH1-binding domains |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FAT1 | up-regulates activity
binding
|
SCRIB |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282694 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23076869 |
FAT1 interacts with Scribble to induce YAP1 phosphorylation, which is involved in the inhibition of cell growth. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
FAT1
- 
- 