Relation Results

Summary

Name ELAVL3
Full Name ELAV-like protein 3
Synonyms Hu-antigen C, HuC, Paraneoplastic cerebellar degeneration-associated antigen, Paraneoplastic limbic encephalitis antigen 21 | HUC, PLE21
Primary ID Q14576
Links - -
Type protein
Relations 2
Function RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437). May also bind poly-A tracts ...
View More

Viewer

Type: Score: Layout: SPV 
0.20.252ELAVL3ADAM10ANK3

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ ELAVL3up-regulates quantity img/direct-activation.png post transcriptional regulation ADAM10 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266864 Homo sapiens
pmid sentence
Neuronal ELAV (nELAV) proteins are RNA-binding proteins which play a physiological role in controlling gene expression in memory formation, and their alteration may contribute to cognitive impairment associated with neurodegenerative pathologies such as Alzheimer's disease (AD). The experiments show for the first time that ADAM10mRNA represents a nELAV target and that these RNA-binding proteins can play a role in the post-transcriptional regulation of ADAM10 expression. nELAV proteins specifically bind the ADAM10 mRNA and this binding is disrupted following Aβ exposure
Publications: 1 Organism: Homo Sapiens
+ ELAVL3down-regulates quantity img/direct_inhibition.png post transcriptional regulation ANK3 0.252
Identifier Residue Sequence Organism Cell Line
SIGNOR-266861 Homo sapiens Neuron
pmid sentence
NElavl (composed of Elavl2, Elavl3, and Elavl4) proteins are the RNA-binding proteins that is specifically expressed in neurons, regulate the alternative splicing of target RNAs, and promote neuronal differentiation and maturation. Here, we found that the alternative splicing of AnkyrinG exon 34 was misregulated in the cerebella of Elavl3-/- mice. AnkyrinG is an essential factor for the formation of neuronal polarity and is required for normal neuronal functions.
Publications: 1 Organism: Homo Sapiens
a simple tooltip