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Summary
Name
POU6F1
View Modifications
Full Name
POU domain, class 6, transcription factor 1
Synonyms
Brain-specific homeobox/POU domain protein 5, Brain-5, Brn-5, mPOU homeobox protein | BRN5, MPOU, TCFB1
Primary ID
Q14863
Links
-
-
Type
protein
Relations
1
Function
Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3'). {ECO:0000250}.
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by mechanism
none
phosphorylation
by effect
none
down-regulates activity
by organism:
none
in vitro
by tissue:
none
by cell-line
none
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Modifications Tables
POU6F1 as Target
Residue
Sequence
Modifier
Effect
Modification
Ser197
KLDITPKsAQKLKPV
AURKA
inhibition
phosphorylation
Relations
Regulator
Mechanism
target
score
ℹ
+
AURKA
down-regulates activity
phosphorylation
POU6F1
0.2
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-273546
Ser197
KLDITPKsAQKLKPV
in vitro
pmid
sentence
31665313
Here, we report that Aurora kinase A phosphorylates mPOU at Ser197 and inhibit its DNA-binding ability.
Publications:
1
Organism:
In Vitro