Summary

Name AGER
Full Name Advanced glycosylation end product-specific receptor
Synonyms Receptor for advanced glycosylation end products | RAGE
Primary ID Q15109
Links - -
Type protein
Relations 4
Function Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

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Relations

Regulator Mechanism target score ℹ
+ HMGB1up-regulates activity img/direct-activation.png binding AGER 0.797
Publications: 1 Organism: Mus Musculus
+ Calprotectin complexup-regulates activity img/direct-activation.png binding AGER 0.339
Publications: 1 Organism: Homo Sapiens
+ S100A9up-regulates activity img/direct-activation.png binding AGER 0.355
Publications: 1 Organism: Homo Sapiens
+ S100A8up-regulates activity img/direct-activation.png binding AGER 0.323
Publications: 1 Organism: Homo Sapiens