Relation Results

Name	PDK3 View Modifications
Full Name	[Pyruvate dehydrogenase
Synonyms	Pyruvate dehydrogenase kinase isoform 3 \| PDHK3
Primary ID	Q15120
Links	- -
Type	protein
Relations	5
Function	Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.