4.0
Summary
| Name |  LLGL1View Modifications |
| Full Name | Lethal |
| Synonyms | LLGL, DLG4, Hugl-1, Human homolog to the D-lgl gene protein | DLG4, HUGL, HUGL1 |
| Primary ID | Q15334 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCI | up-regulates activity 
phosphorylation
|
LLGL1 | 0.629 |
| Publications: | 1 | Organism: | Canis Lupus Familiaris | |
| + | LLGL1 | form complex 
binding
|
Scribble_complex_DLG2-LLGL1_variant | 0.561 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LLGL1 | form complex
binding
|
Scribble_complex_DLG5-LLGL1_variant | 0.465 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LLGL1 | form complex
binding
|
Scribble_complex_DLG4-LLGL1_variant | 0.543 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LLGL1 | form complex
binding
|
Scribble_complex_DLG1-LLGL1_variant | 0.594 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LLGL1 | form complex
binding
|
Scribble_complex_DLG3-LLGL1_variant | 0.594 |
| Publications: | 1 | Organism: | Homo Sapiens | |