3.0
Summary
| Name |  ELOCView Modifications |
| Full Name | Elongin-C |
| Synonyms | Elongin 15 kDa subunit, Elongin-C, EloC, RNA polymerase II transcription factor SIII subunit C, SIII p15 |
| Primary ID | Q15369 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ELOC | up-regulates 
phosphorylation
|
H1-1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ELOC | form complex 
binding
|
BAF250b E3 ligase | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ELOC | down-regulates 
ubiquitination
|
NOTCH4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Hindbrain | |||
| + | ELOC | form complex
binding
|
Elongin E3-Cul-5 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | ELOC | form complex
binding
|
VCB-Cul2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |