Summary

Name TGIF1
Full Name Homeobox protein TGIF1
Synonyms 5'-TG-3'-interacting factor 1 | TGIF
Primary ID Q15583
Links - -
Type protein
Relations 1
Function Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.

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Relations

Regulator Mechanism target score ℹ
+ TGIF1up-regulates img/direct-activation.png binding WWP1 0.335
Publications: 1 Organism: Homo Sapiens