Relation Results

Summary

Name WWP1
Full Name NEDD4-like E3 ubiquitin-protein ligase WWP1
Synonyms Atrophin-1-interacting protein 5, AIP5, HECT-type E3 ubiquitin transferase WWP1, TGIF-interacting ubiquitin ligase 1, Tiul1, WW domain-containing protein 1
Primary ID Q9H0M0
Links - -
Type protein
Relations 12
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ...
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Type: Score: Layout: SPV 
0.2940.7210.3360.20.20.5140.2870.20.278WWP1AMOTL2SMAD7TGIF1WWP2SPARTTGFBR1TP73Ub:E2AMOT

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ WWP1up-regulates activity img/direct-activation.png ubiquitination AMOTL2 0.294
Identifier Residue Sequence Organism Cell Line
SIGNOR-271873 Lys347 EKAGRIEkLESEIQR Homo sapiens HEK-293 Cell
pmid sentence
AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation|Here, we provide evidence that the E3 ligase WWP1 (WW-domain containing protein 1) mono-ubiquitinates AMOTL2 (angiomotin-like 2) at K347 and K408.
Identifier Residue Sequence Organism Cell Line
SIGNOR-271874 Lys408 ANRRLASkTQEAQAG Homo sapiens HEK-293 Cell
pmid sentence
AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation|Here, we provide evidence that the E3 ligase WWP1 (WW-domain containing protein 1) mono-ubiquitinates AMOTL2 (angiomotin-like 2) at K347 and K408.
Publications: 2 Organism: Homo Sapiens
+ WWP1up-regulates activity img/direct-activation.png relocalization, ubiquitination SMAD7 0.721
Identifier Residue Sequence Organism Cell Line
SIGNOR-126578 Homo sapiens
pmid sentence
We found that WWP1 inhibited transcriptional activities induced by TGF-beta. Similar to Smurfs, WWP1 associated with Smad7 and induced its nuclear export, and enhanced binding of Smad7 to TGF-beta type I receptor to cause ubiquitination and degradation of the receptor.
Identifier Residue Sequence Organism Cell Line
SIGNOR-227466 Homo sapiens
pmid sentence
Similar to Smurfs, WWP1 associated with Smad7 and induced its nuclear export, and enhanced binding of Smad7 to TGF-beta type I receptor to cause ubiquitination and degradation of the receptor.
Publications: 2 Organism: Homo Sapiens
+ TGIF1up-regulates img/direct-activation.png binding WWP1 0.336
Identifier Residue Sequence Organism Cell Line
SIGNOR-128854 Homo sapiens
pmid sentence
We demonstrate that tiul1 degrades not only the activated type i receptor in association with smad7 but also smad2 in association with tgif.the steady-state levels of tgif are not affected by tiul1, but the interaction of tiul1 with tgif allows this ubiquitin ligase to target smad2 for degradation.
Publications: 1 Organism: Homo Sapiens
+ WWP2up-regulates activity img/direct-activation.png binding WWP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272231 Homo sapiens HEK-293 Cell
pmid sentence
WWP1 in complex with WWP2 specifically regulates ΔNp73.  In our study, we identified WWP2, an E3 ligase, as a novel p73-associated protein that ubiquitinates and degrades p73. In contrast, WWP2 heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp73. 
Publications: 1 Organism: Homo Sapiens
+ SPARTup-regulates activity img/direct-activation.png binding WWP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261307 Homo sapiens
pmid sentence
Cytosolic endogenous spartin is mono-ubiquitinated and we demonstrate that it interacts via a PPXY motif with the ubiquitin E3 ligases AIP4 [atrophin-interacting protein 4; ITCH (itchy E3 ubiquitin protein ligase homologue] [corrected] and AIP5 (WWP1). Surprisingly, the PPXY motif, AIP4 and AIP5 are not required for spartin's ubiquitination, and so we propose that spartin acts as an adaptor for these proteins.
Publications: 1 Organism: Homo Sapiens
+ WWP1up-regulates img/direct-activation.png binding SMAD7 0.721
Identifier Residue Sequence Organism Cell Line
SIGNOR-126128 Homo sapiens
pmid sentence
Wwp1 associated with smad7 and induced its nuclear export, and enhanced binding of smad7 to tgf-beta type i receptor to cause ubiquitination and degradation of the receptor.
Publications: 1 Organism: Homo Sapiens
+ WWP1down-regulates img/direct_inhibition.png ubiquitination TGFBR1 0.514
Identifier Residue Sequence Organism Cell Line
SIGNOR-126581 Homo sapiens
pmid sentence
Similar to smurfs, wwp1 associated with smad7 and induced its nuclear export, and enhanced binding of smad7 to tgf-beta type i receptor to cause ubiquitination and degradation of the receptor. Consistent with these results, wwp1 inhibited phosphorylation of smad2 induced by tgf-beta. Wwp1 thus negatively regulates tgf-beta signaling in cooperation with smad7
Publications: 1 Organism: Homo Sapiens
+ WWP1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TP73 0.287
Identifier Residue Sequence Organism Cell Line
SIGNOR-272232 Homo sapiens HEK-293 Cell
pmid sentence
WWP1 in complex with WWP2 specifically regulates ΔNp73.  In our study, we identified WWP2, an E3 ligase, as a novel p73-associated protein that ubiquitinates and degrades p73. In contrast, WWP2 heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp73. 
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination WWP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271293 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
+ WWP1up-regulates quantity by stabilization img/direct-activation.png ubiquitination AMOT 0.278
Identifier Residue Sequence Organism Cell Line
SIGNOR-275847
pmid sentence
Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3. Such phosphorylation, in turn, enables the ubiquitin ligase atrophin-1 interacting protein (AIP)4 to bind, ubiquitinate, and stabilize Amot130
Publications: 1
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