3.0
Summary
| Name |  HERC1
|
| Full Name | Probable E3 ubiquitin-protein ligase HERC1 |
| Synonyms | HECT domain and RCC1-like domain-containing protein 1, HECT-type E3 ubiquitin transferase HERC1, p532, p619 | |
| Primary ID | Q15751 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. |
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ubiquitination
ubiquitination