| Name
|
 HERC1
|
| Full Name |
Probable E3 ubiquitin-protein ligase HERC1 |
| Synonyms |
HECT domain and RCC1-like domain-containing protein 1, HECT-type E3 ubiquitin transferase HERC1, p532, p619 | |
| Primary ID |
Q15751 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. |
3.0
ubiquitination