4.0
Summary
| Name |  SLC1A5
|
| Full Name | Neutral amino acid transporter B(0) |
| Synonyms | ATB(0), Baboon M7 virus receptor, RD114/simian type D retrovirus receptor, Sodium-dependent neutral amino acid transporter type 2, Solute carrier family 1 member 5 | ASCT2, M7V1, RDR, RDRC |
| Primary ID | Q15758 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Pathways | Glutamine metabolism |
| Function | Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519, PubMed:29872227). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SLC1A5 | up-regulates quantity 
relocalization
|
L-glutamine zwitterion | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glutamine metabolism | |||
| + | MTFP1 | up-regulates quantity by expression 
transcriptional regulation
|
SLC1A5 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MYC | up-regulates quantity by expression
transcriptional regulation
|
SLC1A5 | 0.413 |
| Publications: | 1 | Organism: | Homo Sapiens | |