| Identifier | 
									Residue | 
									Sequence | 
									Organism | 
									Cell Line | 
								 
							
								
								
									| SIGNOR-279114 | 
									 | 
									 | 
									Homo sapiens | 
									 | 
								
								 
									| pmid | 
									sentence | 
								 
								 
									| 32683896 | 
								
									Conclusions : Unlike other kinases (PKA, CaMKII) that increase RyR2 activity, SPEG phosphorylation reduces RyR2 mediated SR Ca 2+ -release.|Further, we show that SPEG phosphorylates RyR2 at a previously uncharacterized serine (S2367) located in the central domain of the channel.  xref  Importantly, in contrast to previously studied phosphorylation sites that activate RyR2 (e.g. S2808, S2814), we show that SPEG mediated RyR2-S2367 phosphorylation suppresses pathogenic diastolic SR Ca 2+ -leak. | 
								 
						 
                     |