Relation Results

Summary

Name ATP6AP1
Full Name V-type proton ATPase subunit S1
Synonyms V-ATPase subunit S1, Protein XAP-3, V-ATPase Ac45 subunit, V-ATPase S1 accessory protein, Vacuolar proton pump subunit S1 | ATP6IP1, ATP6S1, VATPS1, XAP3
Primary ID Q15904
Links - -
Type protein
Relations 3
Function Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guid ...
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Type: Score: Layout: SPV 
0.20.5870.291ATP6AP1HIF1AV-ATPaseRAB7A

Relations

Regulator
Mechanism
target
score
+ down-regulates quantity by destabilization img/indirect_inhibition.png HIF1A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261347 Homo sapiens
pmid sentence
Depletion or inhibition of the V-ATPase stabilises HIF1α in aerobic conditions.
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding V-ATPase 0.587
Identifier Residue Sequence Organism Cell Line
SIGNOR-277752 Homo sapiens
pmid sentence
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes.
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAB7A 0.291
Identifier Residue Sequence Organism Cell Line
SIGNOR-261484
pmid sentence
We found that Ac45 colocalized with Rab7 in resorbing osteoclasts cultured on bone slices (Fig. 6A). In addition, a co-immunoprecipitation assay revealed that Ac45 directly interacted with Rab7| Therefore, Ac45’s role in extracellular acidification, lysosomal trafficking, and cathepsin K exocytosis may be through the Rab7 pathway.
Publications: 1
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