| + |
ATP6V0E1 | form complex 
binding
|
V-ATPase |
0.57 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277747 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6AP1 | form complex
binding
|
V-ATPase |
0.591 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277752 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6V0B | form complex
binding
|
V-ATPase |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277758 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
V-ATPase | up-regulates quantity 
relocalization
|
cholesterol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277760 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 31827278 |
Accumulation of V-ATPase at the plasma membrane is necessary for the cholesterol-dependent plasma-membrane association of RAC1, a prerequisite for the stimulation of membrane ruffling and macropinocytosis. In line with these observations, immunohistochemical staining of V-ATPase in human pancreatic ductal adenocarcinoma (PDAC) specimens revealed prominent staining at the cell periphery in neoplastic lesions, in con- trast to the predominantly cytoplasmic staining observed in adjacent normal tissues (Fig. 2e). Thus, mutant RAS-dependent plasma mem- brane V-ATPase displayed preferential accumulation in membrane ruffles, consistent with patterns observed in invasive breast, melanoma and pancreatic cancer cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6V1C1 | form complex
binding
|
V-ATPase |
0.78 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277743 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6V1F | form complex
binding
|
V-ATPase |
0.768 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277755 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6V1A | form complex
binding
|
V-ATPase |
0.766 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277757 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6V1H | form complex
binding
|
V-ATPase |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277749 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCIRG1 | form complex
binding
|
V-ATPase |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277764 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6V0C | form complex
binding
|
V-ATPase |
0.743 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277750 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6V0D2 | form complex
binding
|
V-ATPase |
0.799 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277746 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6V1G2 | form complex
binding
|
V-ATPase |
0.738 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277745 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6V1E2 | form complex
binding
|
V-ATPase |
0.746 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277748 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KRAS | up-regulates activity
relocalization
|
V-ATPase |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277759 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 31827278 |
V-ATPase is required for macropinocytosis. oncogenic RAS-dependent recruitment of V-ATPase to the plasma membrane constitutes an essential step in induction of macropinocytosis. Here we identify vacuolar ATPase (V-ATPase) as an essential regulator of RAS-induced macropinocytosis. Oncogenic RAS promotes the translocation of V-ATPase from intracellular membranes to the plasma membrane via a pathway that requires the activation of protein kinase A by a bicarbonate- dependent soluble adenylate cyclase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6V1B1 | form complex
binding
|
V-ATPase |
0.791 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277744 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNASEK | form complex
binding
|
V-ATPase |
0.23 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277753 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6AP2 | form complex
binding
|
V-ATPase |
0.511 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277751 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6V0A2 | form complex
binding
|
V-ATPase |
0.758 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277754 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP6V1D | form complex
binding
|
V-ATPase |
0.801 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277756 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33065002 |
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V1 complex for ATP hydrolysis and a membrane-embedded Vo complex for proton transfer. They play important roles in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PKA | up-regulates activity
relocalization
|
V-ATPase |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277763 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 31827278 |
It is worth noting that CA-PKA failed to rescue macropinocytosis in KRAS-knockdown cells, indicating that whereas PKA activation is necessary for mutant KRAS-dependent plasma membrane translocation of V-ATPase and induction of macropinocytosis, it is not sufficient (Extended Data Fig. 6e). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
V-ATPase
CPX-6904