| + |
TAF12 | form complex 
binding
|
SAGA complex |
0.746 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269580 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
Here we present the cryogenic-electron microscopy (cryo-EM) structure of human SAGA (hSAGA)|Human SAGA is a 20-subunit, 1.4-MDa complex with five functional modules (Fig. (Fig.1a):1a): a scaffolding core that includes TBP-associated factors (TAFs); a TRRAP (Transformation/Transcription domain Associated Protein) containing a phosphoinositide-3-kinase (PI3K)-related pseudoprotein kinase (ΨPIKK); a histone acetyltransferase (HAT); a deubiquitinase (DUB) and a metazoan-specific splicing (SPL) module |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAF12 | up-regulates activity 
binding
|
ATF7 |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-225249 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 15735663 |
We show that overexpression of hsTAF12 potentiates ATF7-induced transcriptional activation through direct interaction with ATF7, suggesting that TAF12 is a functional partner of ATF7. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
TAF12 | form complex
binding
|
TFIID |
0.885 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263924 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TAF12
- 
- 