| + |
PFKFB4 | up-regulates activity 
phosphorylation
|
NCOA3 |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267269 |
Ser857 |
PPYNRAVsLDSPVSV |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29615789 |
PFKFB4, a regulatory enzyme that synthesizes an allosteric stimulator of glycolysis2, was found to be a robust stimulator of SRC-3 that co-activates estrogen receptor (ER). PFKFB4 phosphorylates SRC-3 at serine 857 (S857) enhancing its transcriptional activity, whereas either suppression of PFKFB4 or ectopic expression of a phosphorylation-deficient SRC-3 mutant S857A (SRC-3S857A) significantly abolishes SRC-3-mediated transcriptional output |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PFKFB4 | up-regulates quantity
chemical modification
|
beta-D-fructofuranose 2,6-bisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267264 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15170386 |
Fru-2,6-P2 (fructose 2,6-bisphosphate) is a signal molecule that controls glycolysis. Since its discovery more than 20 years ago, inroads have been made towards the understanding of the structure– function relationships in PFK-2 (6-phosphofructo-2-kinase)/ FBPase-2 (fructose-2,6-bisphosphatase), the homodimeric bifunctional enzyme that catalyses the synthesis and degradation of Fru-2,6-P2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PFKFB4 | down-regulates quantity 
chemical modification
|
beta-D-fructofuranose 2,6-bisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267272 |
|
|
in vitro |
|
| pmid |
sentence |
| 30553771 |
PFKFB3 has the highest kinase activity to shunt glucose toward glycolysis, whereas PFKFB4 has more FBPase-2 activity, redirecting glucose toward the pentose phosphate pathway, providing reducing power for lipid biosynthesis and scavenging reactive oxygen species |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PFKFB4 | down-regulates quantity
chemical modification
|
β-D-fructose 6-phosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15170386 |
Fru-2,6-P2 (fructose 2,6-bisphosphate) is a signal molecule that controls glycolysis. Since its discovery more than 20 years ago, inroads have been made towards the understanding of the structure– function relationships in PFK-2 (6-phosphofructo-2-kinase)/ FBPase-2 (fructose-2,6-bisphosphatase), the homodimeric bifunctional enzyme that catalyses the synthesis and degradation of Fru-2,6-P2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PFKFB4 | up-regulates quantity
chemical modification
|
β-D-fructose 6-phosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268118 |
|
|
in vitro |
|
| pmid |
sentence |
| 30553771 |
PFKFB3 has the highest kinase activity to shunt glucose toward glycolysis, whereas PFKFB4 has more FBPase-2 activity, redirecting glucose toward the pentose phosphate pathway, providing reducing power for lipid biosynthesis and scavenging reactive oxygen species |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
PFKFB4
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