| + |
CAMK1 | down-regulates 
phosphorylation
|
NUMB |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149993 |
Ser276 |
EQLARQGsFRGFPAL |
Homo sapiens |
|
| pmid |
sentence |
| 17022975 |
Based on experiments using numb mutants, both the initial phosphorylation of ser(264) and the subsequent phosphorylation of ser(283) are sufficient to abolish the binding of numb to ap-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AAK1 | up-regulates 
phosphorylation
|
NUMB |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179606 |
Thr102 |
LRVVDEKtKDLIVDQ |
Homo sapiens |
|
| pmid |
sentence |
| 18657069 |
Collectively, these observations demonstrate that numb endocytic activity is regulated by aak1 and that phosphorylation may be a critical step in promoting coated pit maturation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AAK1 |
phosphorylation
|
NUMB |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179610 |
Thr102 |
LRVVDEKtKDLIVDQ |
Homo sapiens |
|
| pmid |
sentence |
| 18657069 |
Numb is phosphorylated by aak1, while little aak1-dependent phosphorylation is observed in t102a numb immunoprecipitants |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSI2 | down-regulates quantity by repression 
transcriptional regulation
|
NUMB |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169848 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 21084860 |
Msi2 was shown to be upregulated in blast crisis cml and to negatively regulate expression ofnumb. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUMB | down-regulates
|
NOTCH |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255375 |
|
|
|
|
| pmid |
sentence |
| 12361602 |
Therefore, these genetic data further support the hypothesis that activation of Notch-1 promotes a less committed myogenic phenotype and that the attenuation of Notch-1 activity by Numb promotes progression along the myogenic lineage toward a myoblast cell fate. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255374 |
|
|
|
|
| pmid |
sentence |
| 12361602 |
Numb is an inhibitor of Notch signaling that interacts with the intracellular portion of Notch and antagonizes its activity by preventing nuclear translocation |
|
| Publications: |
2 |
| Tissue: |
Skeletal Muscle |
| + |
NUMB | down-regulates
binding
|
GLI1 |
0.624 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167841 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20818436 |
The consequent activation of_ itch, together with the recruitment of gli1 through direct binding with_ numb, allows gli1 to enter into the complex, resulting in gli1 ubiquitination and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LNX1 | down-regulates
ubiquitination
|
NUMB |
0.742 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112201 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11782429 |
Lnx functions as a ring type e3 ubiquitin ligase that targets the cell fate determinant numb for ubiquitin-dependent degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LNX2 | down-regulates quantity by destabilization
polyubiquitination, ubiquitination
|
NUMB |
0.605 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272423 |
|
|
in vitro |
|
| pmid |
sentence |
| 26451611 |
Polyubiquitination of Human Numb by LNX2. The Zn-RING-Zn domain of LNX2 is a dimer and assumes a rigid elongated structure that undergoes autoubiquitination and undergoes N-terminal polyubiquitination. LNX2 can bind numb and induce its ubiquitination and subsequent proteasomal degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278818 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32714586 |
Notably LNX2 knockdown caused an increase in NUMB levels and decreased levels of the NOTCH2 intracellular domain , as well as decreased expression of the NOTCH target gene Hes1 .|They also showed for the first time that LNX2 could indeed ubiquitinate NUMB, something that had previously only been shown for LNX1. |
|
| Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
| + |
NUMB | down-regulates
binding
|
MDM2 |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20940030 |
Numb interacts with mdm2, and inhibits its ubiquitin-ligase function on tp53 (which in itself is inhibitory for tp53), thus numb activates (b) tp53 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC30A9 | down-regulates quantity by destabilization
ubiquitination
|
NUMB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113704 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11782429 |
Lnx functions as a ring type e3 ubiquitin ligase that targets the cell fate determinant numb for ubiquitin-dependent degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUMB | up-regulates
binding
|
ITCH |
0.616 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167844 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20818436 |
Numb activates the catalytic activity of itch, releasing it from an inhibitory intramolecular interaction between its homologous to e6-ap c-terminus and ww domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIAH1 | down-regulates
ubiquitination
|
NUMB |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113469 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11752454 |
We report that siah-1 interacts directly with and promotes the degradation of the cell fate regulator numb. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUMB | up-regulates
binding
|
TP53 |
0.515 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178668 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 18492217 |
Numb can actually interact in vivo with endogenous mdm2 and p53, resulting in a trimeric complex between the three proteins [10]. This interaction appears to regulate the stability of p53, as reduction of numb levels by rna interference (rnai) causes a decrease in the half-life of p53 and consequently a reduction in steady-state levels of the protein. Consistent with this observation, overexpression of numb increases the level of p53 in both unstressed and stressed cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCI | down-regulates
phosphorylation
|
NUMB |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156765 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17609107 |
Numb is regulated by phosphorylation since the protein is released from ccss and no longer binds integrins when phosphorylated by atypical protein kinase c (apkc). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDM2 | down-regulates
ubiquitination
|
NUMB |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99497 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 12646252 |
These data strongly suggest thatmdm2functions as the ubiquitin ligase toward hnumb and that it induces its degradation in intact cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSI1 | down-regulates
binding
|
NUMB |
0.446 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165617 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20477901 |
The study confirmed p21(cip1) and numb proteins as targets of musashi1, suggesting additionally p27(kip1) in cell-cycle regulation and jagged-1 in notch . |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SATB1 | down-regulates quantity by repression
transcriptional regulation
|
NUMB |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-224835 |
|
|
Homo sapiens |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 23563689 |
Satb1 simultaneously repressed sets of genes encoding molecules involved in HSC activation and cellular polarity, including Numb and Myc |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUMB | up-regulates 
|
TP53 |
0.515 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168457 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20940030 |
Numb interacts with mdm2, and inhibits its ubiquitin-ligase function on tp53 (which in itself is inhibitory for tp53), thus numb activates (b) tp53. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUMB | down-regulates quantity by destabilization
ubiquitination
|
NOTCH1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99762 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12682059 |
Mammalian numb proteins promote notch1 receptor ubiquitination and degradation of the notch1 intracellular domain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling and Myogenesis |
4.0
NUMB
- 
- 