Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-149630 |
Thr379 |
WSTSSDLtISISEDD |
Homo sapiens |
|
pmid |
sentence |
16980960 |
Here, we identify a novel centrosomal substrate of plk1, kizuna (kiz), depletion of which causes fragmentation and dissociation of the pericentriolar material from centrioles at prometaphase, resulting in multipolar spindles. Plk1 maintains the integrity of the spindle poles by phosphorylating kiz. |
|