3.0
Summary
| Name |  ERCC6LView Modifications |
| Full Name | DNA excision repair protein ERCC-6-like |
| Synonyms | ATP-dependent helicase ERCC6-like, PLK1-interacting checkpoint helicase, Tumor antigen BJ-HCC-15 | PICH |
| Primary ID | Q2NKX8 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin (PubMed:17218258). Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). |
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phosphorylation