Summary

Name MGAT5B
Full Name Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
Synonyms Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B, GlcNAc-T Vb, GNT-Vb, hGnTVb, Mannoside acetylglucosaminyltransferase 5B, N-acetylglucosaminyl-transferase Vb, N-acetylglucosaminyltransferase IX, GNT-IX | KIAA2008
Primary ID Q3V5L5
Links - -
Type protein
Relations 2
Function Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MGAT5B 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MGAT5B 0.255
Publications: 1 Organism: Mus Musculus