3.0
Summary
| Name |  MGAT5B
|
| Full Name | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B |
| Synonyms | Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B, GlcNAc-T Vb, GNT-Vb, hGnTVb, Mannoside acetylglucosaminyltransferase 5B, N-acetylglucosaminyl-transferase Vb, N-acetylglucosaminyltransferase IX, GNT-IX | KIAA2008 |
| Primary ID | Q3V5L5 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. |
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transcriptional regulation