Summary

Name ARHGAP29
Full Name Rho GTPase-activating protein 29
Synonyms PTPL1-associated RhoGAP protein 1, Rho-type GTPase-activating protein 29 | PARG1
Primary ID Q52LW3
Links - -
Type protein
Relations 1
Function GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.

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Relations

Regulator Mechanism target score ℹ
+ ARHGAP29down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.533
Publications: 1 Organism: Homo Sapiens