Relation Results

Summary

Name	SETMAR View Modifications
Full Name	Histone-lysine N-methyltransferase SETMAR
Synonyms	SET domain and mariner transposase fusion protein, Metnase \|
Primary ID	Q53H47
Links	- -
Type	protein
Relations	2
Function	Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750). {ECO:0000269\|PubMed:16332963, ECO:0000269\|PubMed:16672366, ECO:0000269\|PubMed:17403897, ECO:0000269\|PubMed:17877369, ECO:0000269\|PubMed:18790802, ECO:0000269\|PubMed:20457750, ECO:0000269\|PubMed:20521842, ECO:0000269\|PubMed:21187428, ECO:0000269\|PubMed:22231448, ECO:0000269\|PubMed:24573677, ECO:0000303\|PubMed:18263876}.