Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268299 |
|
|
Rattus norvegicus |
Neuron |
pmid |
sentence |
18685031 |
Together, our results provide strong evidence that Yif1B is a member of the ER/Golgi trafficking machinery, which plays a key role in specific targeting of 5-HT(1A)R to the neuronal dendrites. This finding opens up new pathways for the study of 5-HT(1A)R regulation by partner proteins and for the development of novel antidepressant drugs.|We confirmed 5-HT(1A)R-Yif1B interaction by glutathione S-transferase pull-down experiments using rat brain extracts and transfected cell lines. |
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